Semax

Semax is a synthetic heptapeptide analog of the ACTH(4-7) fragment used in neurochemical laboratory research. Studies have examined its interaction with neuropeptide signaling, BDNF-pathway activity, and melanocortin-receptor models. Supplied as lyophilized material for qualified in-vitro research.

Compound specifications: Lyophilized powder in sealed vials. Purity verified at ≥99% by independent third-party HPLC analysis. Store in a cool, dry environment; refrigerate after reconstitution per standard laboratory protocol.

What is Semax?

Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) built on the ACTH(4-7) fragment of adrenocorticotropic hormone with a C-terminal Pro-Gly-Pro extension that improves its stability in research settings. It has been studied for decades, originally within the Russian research and pharmacopeia tradition, and has a growing international literature.

Research interest in Semax centers on neurotropic signaling — how the peptide influences gene expression and neurotrophin pathways in experimental models. It is supplied here as high-purity lyophilized material strictly for qualified research use.

Mechanism of Action — Research Overview

Semax's ACTH(4-7) core does not drive corticosteroid release in research models; instead, studies examine melanocortin-receptor-associated and non-receptor pathways in neural tissue models. Published work reports Semax-associated modulation of BDNF and NGF expression markers, and effects on dopaminergic and serotonergic signaling measures in preclinical systems.

Recent pharmacology literature continues to map its molecular targets — including reported interaction with opioid-receptor-gene regulatory pathways — keeping Semax an active subject in neuropeptide research.

Research Applications

• Neurotrophin (BDNF/NGF) expression research
• Melanocortin-system and neuropeptide signaling studies
• Cognitive-process research models
• Ischemia and neural stress-response models
• ACTH-fragment comparative pharmacology

Semax Specifications

Laboratory Handling & Storage

Standard small-peptide handling: sterile technique, PPE, protection from light and moisture, and documented lot tracking.

Certificate of Analysis & Quality Assurance

Every batch of Semax is verified by independent third-party HPLC analysis (identity and purity) before it ships. The certificate of analysis for the current batch is linked on this page and can be reviewed here: view batch COA. Documentation of lot number, test date, and method accompanies each batch.

References

1. Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice. Br J Pharmacol. 2025. PMID: 40692165
2. Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions. J Am Acad Orthop Surg Glob Res Rev. 2026. PMID: 41490200

Note: Semax is supplied strictly for laboratory research use only. It is not approved for human or veterinary use, and nothing on this page is medical advice or a health claim. All described findings reflect preclinical or published research contexts.

Shipping, Handling & Guarantee

• Fast U.S. shipping: Orders placed before 2:00 PM CT ship the same business day from Minneapolis, MN. Free shipping on orders over $100.
• Lab safety profile: Supplied for laboratory research use only. Handle using appropriate personal protective equipment in a suitable laboratory setting. Not for human or veterinary use.
• Order guarantee: If your order arrives damaged, incorrect, or incomplete, contact us within 48 hours of delivery with photos and we will make it right. See our Return & Refund Policy.