NAD+

NAD+ (nicotinamide adenine dinucleotide) is an essential cellular coenzyme involved in redox reactions and energy metabolism. Laboratory research has explored its role in sirtuin and PARP pathway activity, mitochondrial function models, and age-related cellular research. Supplied as lyophilized material for qualified in-vitro research.

Compound specifications: Lyophilized powder in sealed vials. Purity verified at ≥99% by independent third-party HPLC analysis. Store in a cool, dry environment; refrigerate after reconstitution per standard laboratory protocol.

What is NAD+?

NAD+ (β-nicotinamide adenine dinucleotide) is a ubiquitous cellular coenzyme central to redox metabolism and an obligatory substrate for sirtuins, PARPs, and other NAD-dependent enzymes studied across aging and metabolism research. It is one of the most referenced metabolites in the biochemical literature.

Research interest in NAD+ has intensified around age-associated declines in cellular NAD+ pools observed in study models, and around the NAD+ salvage and de-novo synthesis pathways that maintain them. It is supplied here as high-purity lyophilized material strictly for qualified research use.

Mechanism of Action — Research Overview

NAD+ functions in research systems as an electron carrier in glycolysis, the TCA cycle, and oxidative phosphorylation, cycling between oxidized (NAD+) and reduced (NADH) states. Beyond redox chemistry, studies examine its role as a consumed substrate for sirtuin deacetylases and PARP DNA-repair enzymes, linking NAD+ availability to gene-regulation and stress-response pathways.

Published models also investigate NAD+/NADH ratio dynamics, mitochondrial NAD+ compartmentalization, and the influence of precursor availability (NR, NMN, nicotinamide) on intracellular NAD+ pools.

Research Applications

• Cellular redox metabolism and bioenergetics research
• Sirtuin and PARP enzyme-substrate studies
• NAD+ salvage-pathway and precursor research
• Mitochondrial function models
• Age-related metabolic research

NAD+ Specifications

Laboratory Handling & Storage

Handle as a standard hygroscopic research compound: minimize moisture exposure, use sterile technique and PPE, and document preparation conditions and lot numbers.

Certificate of Analysis & Quality Assurance

Every batch of NAD+ is verified by independent third-party HPLC analysis (identity and purity) before it ships. The certificate of analysis for the current batch is linked on this page and can be reviewed here: view batch COA. Documentation of lot number, test date, and method accompanies each batch.

References

1. NAD(+) metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021. PMID: 33353981
2. The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update. Adv Nutr. 2023. PMID: 37619764

Note: NAD+ is supplied strictly for laboratory research use only. It is not approved for human or veterinary use, and nothing on this page is medical advice or a health claim. All described findings reflect preclinical or published research contexts.

Shipping, Handling & Guarantee

• Fast U.S. shipping: Orders placed before 2:00 PM CT ship the same business day from Minneapolis, MN. Free shipping on orders over $100.
• Lab safety profile: Supplied for laboratory research use only. Handle using appropriate personal protective equipment in a suitable laboratory setting. Not for human or veterinary use.
• Order guarantee: If your order arrives damaged, incorrect, or incomplete, contact us within 48 hours of delivery with photos and we will make it right. See our Return & Refund Policy.