KPV

KPV (Lys-Pro-Val) is a tripeptide corresponding to the C-terminal sequence of alpha-MSH. Laboratory research has explored its role in inflammatory-pathway models, including NF-kB signaling and cytokine-activity studies in vitro. Supplied as lyophilized material for qualified research applications.

Compound specifications: Lyophilized powder in sealed vials. Purity verified at ≥99% by independent third-party HPLC analysis. Store in a cool, dry environment; refrigerate after reconstitution per standard laboratory protocol.

What is KPV?

KPV (Lys-Pro-Val) is the C-terminal tripeptide of α-melanocyte-stimulating hormone (α-MSH 11-13). It retains a portion of the parent hormone's studied biological activity in research models while lacking the melanocortin-receptor-driven pigmentary effects associated with the full-length peptide — a separation that has made it a distinct research subject.

The KPV literature concentrates on inflammatory-signaling research, including intestinal and epithelial models. It is supplied here as high-purity lyophilized material strictly for qualified research use.

Mechanism of Action — Research Overview

Research models examine KPV's influence on inflammatory-pathway markers — including NF-κB and cytokine signaling — through mechanisms studied as largely independent of classical melanocortin-receptor activation. Cellular uptake via the PepT1 transporter is a recurring theme in the intestinal-epithelium literature.

Studies describe pathway-modulation effects on immune-signaling cascades in cell and animal models, positioning KPV as a small, transporter-accessible probe for inflammatory-pathway research.

Research Applications

• Inflammatory-signaling and NF-κB pathway research
• Intestinal-epithelium and PepT1-transport studies
• Cytokine-signaling models
• α-MSH fragment comparative research
• Epithelial-barrier research models

KPV Specifications

Laboratory Handling & Storage

Standard small-peptide handling: sterile technique, PPE, moisture and light protection, and lot documentation.

Certificate of Analysis & Quality Assurance

Every batch of KPV is verified by independent third-party HPLC analysis (identity and purity) before it ships. The certificate of analysis for the current batch is linked on this page and can be reviewed here: view batch COA. Documentation of lot number, test date, and method accompanies each batch.

References

1. alpha-Melanocyte-stimulating hormone, MSH 11-13 KPV and adrenocorticotropic hormone signalling in human keratinocyte cells. J Invest Dermatol. 2004. PMID: 15102092
2. Effects of the COOH-terminal tripeptide alpha-MSH(11-13) on corneal epithelial wound healing: role of nitric oxide. Exp Eye Res. 2006. PMID: 16965771

Note: KPV is supplied strictly for laboratory research use only. It is not approved for human or veterinary use, and nothing on this page is medical advice or a health claim. All described findings reflect preclinical or published research contexts.

Shipping, Handling & Guarantee

• Fast U.S. shipping: Orders placed before 2:00 PM CT ship the same business day from Minneapolis, MN. Free shipping on orders over $100.
• Lab safety profile: Supplied for laboratory research use only. Handle using appropriate personal protective equipment in a suitable laboratory setting. Not for human or veterinary use.
• Order guarantee: If your order arrives damaged, incorrect, or incomplete, contact us within 48 hours of delivery with photos and we will make it right. See our Return & Refund Policy.