PP-Mots | Prestige Peptides

MOTS-c

10mg / 1 Vial
$45.00
$45.00
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MOTS-c
MOTS-c

RESEARCH USE ONLY

For qualified in-vitro laboratory research only. Not for human consumption, veterinary use, clinical, diagnostic, or therapeutic use. Not evaluated by the FDA. Purchasers must be 21 years of age or older.

MOTS-c

$45.00
$45.00
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Bundle & save 3-vial packs 15% off · 5-vial packs 25% off · 10-vial packs 35% off — already applied in pack prices
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MOTS-c is a 16-amino-acid mitochondrial-derived peptide studied in laboratory research on cellular energy homeostasis and metabolic-stress response pathways, including AMPK-signaling models. Supplied as lyophilized material for qualified in-vitro research.

Compound specifications: Lyophilized powder in sealed vials. Purity verified at ≥99% by independent third-party HPLC analysis. Store in a cool, dry environment; refrigerate after reconstitution per standard laboratory protocol.

Research use notice

Reserved for qualified in-vitro laboratory research only. Not for human consumption, veterinary use, clinical, diagnostic, or therapeutic use. Purchasers must be 21 years of age or older and accept the Research Use Only Agreement before ordering.

What is MOTS-c?

MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) is a 16-amino-acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA gene. It belongs to a recently characterized class of signaling peptides produced by the mitochondrial genome, and has become a prominent subject in metabolic and exercise-physiology research models.

Published research describes MOTS-c as a retrograde signaling molecule — a peptide through which mitochondria communicate stress and energy status to the wider cell. It is supplied here as high-purity lyophilized material strictly for qualified research use.

Mechanism of Action — Research Overview

Research models associate MOTS-c with AMPK-pathway activation and folate-cycle/AICAR-related metabolic signaling. Studies examine how it influences glucose utilization, fatty-acid oxidation markers, and cellular stress-adaptation responses in preclinical systems.

A recurring theme in the literature is its exercise-mimetic character in animal models: MOTS-c levels respond to physical activity, and experimental administration is studied for effects on metabolic flexibility and age-related metabolic decline pathways.

Research Applications

  • Mitochondrial signaling and retrograde-communication research
  • AMPK-pathway and cellular energy-sensing studies
  • Metabolic flexibility and substrate-utilization models
  • Exercise-mimetic and muscle-metabolism research
  • Age-related metabolic-decline pathway investigations

MOTS-c Specifications

Format Lyophilized powder in sealed 3 mL glass vial (10mg / 20mg)
CAS Number 1627580-64-6
Chemical Formula C101H152N28O22S2
Molecular Weight ≈ 2174.6 g/mol
PubChem CID 146675088
Synonyms Mitochondrial-derived peptide MOTS-c, mtORF-12S peptide
Storage Store lyophilized at −20°C, sealed, protected from light and moisture. Refrigerate after reconstitution per standard laboratory protocol.

Laboratory Handling & Storage

Handle with sterile technique and appropriate PPE. Protect from moisture and repeated freeze–thaw after reconstitution; record lot numbers in experimental documentation.

Certificate of Analysis & Quality Assurance

Every batch of MOTS-c is verified by independent third-party HPLC analysis (identity and purity) before it ships. The certificate of analysis for the current batch is linked on this page and can be reviewed here: view batch COA. Documentation of lot number, test date, and method accompanies each batch.

References

  1. MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation. Front Endocrinol (Lausanne). 2023. PMID: 36761202
  2. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015. PMID: 25738459

Note: MOTS-c is supplied strictly for laboratory research use only. It is not approved for human or veterinary use, and nothing on this page is medical advice or a health claim. All described findings reflect preclinical or published research contexts.

Shipping, Handling & Guarantee

  • Fast U.S. shipping: Orders placed before 2:00 PM CT ship the same business day from Minneapolis, MN. Free shipping on orders over $100.
  • Lab safety profile: Supplied for laboratory research use only. Handle using appropriate personal protective equipment in a suitable laboratory setting. Not for human or veterinary use.
  • Order guarantee: If your order arrives damaged, incorrect, or incomplete, contact us within 48 hours of delivery with photos and we will make it right. See our Return & Refund Policy.

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