{"product_id":"pp-07","title":"Semax","description":"\u003cp\u003eSemax is a synthetic heptapeptide analog of the ACTH(4-7) fragment used in neurochemical laboratory research. Studies have examined its interaction with neuropeptide signaling, BDNF-pathway activity, and melanocortin-receptor models. Supplied as lyophilized material for qualified in-vitro research.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eCompound specifications:\u003c\/strong\u003e Lyophilized powder in sealed vials. Purity verified at ≥99% by independent third-party HPLC analysis. Store in a cool, dry environment; refrigerate after reconstitution per standard laboratory protocol.\u003c\/p\u003e\u003cdiv class=\"pp-product-notes\"\u003e\n\u003cdiv class=\"pp-product-notes__item\"\u003e\n\u003cp class=\"pp-product-notes__label\"\u003eResearch use notice\u003c\/p\u003e\n\u003cp\u003eReserved for qualified in-vitro laboratory research only. Not for human consumption, veterinary use, clinical, diagnostic, or therapeutic use. Purchasers must be 21 years of age or older and accept the Research Use Only Agreement before ordering.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\n\u003ch2\u003eWhat is Semax?\u003c\/h2\u003e\n\u003cp\u003eSemax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) built on the ACTH(4-7) fragment of adrenocorticotropic hormone with a C-terminal Pro-Gly-Pro extension that improves its stability in research settings. It has been studied for decades, originally within the Russian research and pharmacopeia tradition, and has a growing international literature.\u003c\/p\u003e\n\u003cp\u003eResearch interest in Semax centers on neurotropic signaling — how the peptide influences gene expression and neurotrophin pathways in experimental models. It is supplied here as high-purity lyophilized material strictly for qualified research use.\u003c\/p\u003e\n\u003ch2\u003eMechanism of Action — Research Overview\u003c\/h2\u003e\n\u003cp\u003eSemax's ACTH(4-7) core does not drive corticosteroid release in research models; instead, studies examine melanocortin-receptor-associated and non-receptor pathways in neural tissue models. Published work reports Semax-associated modulation of BDNF and NGF expression markers, and effects on dopaminergic and serotonergic signaling measures in preclinical systems.\u003c\/p\u003e\n\u003cp\u003eRecent pharmacology literature continues to map its molecular targets — including reported interaction with opioid-receptor-gene regulatory pathways — keeping Semax an active subject in neuropeptide research.\u003c\/p\u003e\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eNeurotrophin (BDNF\/NGF) expression research\u003c\/li\u003e\n\u003cli\u003eMelanocortin-system and neuropeptide signaling studies\u003c\/li\u003e\n\u003cli\u003eCognitive-process research models\u003c\/li\u003e\n\u003cli\u003eIschemia and neural stress-response models\u003c\/li\u003e\n\u003cli\u003eACTH-fragment comparative pharmacology\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eSemax Specifications\u003c\/h2\u003e\n\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eFormat\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eLyophilized powder in sealed 3 mL glass vial (10mg)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eCAS Number\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e80714-61-0\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eChemical Formula\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eC37H51N9O10S\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e≈ 813.9 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003ePubChem CID\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e9811102\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSynonyms\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eACTH(4-7)-Pro-Gly-Pro, Met-Glu-His-Phe-Pro-Gly-Pro\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eStore lyophilized at −20°C, sealed, protected from light and moisture. Refrigerate after reconstitution per standard laboratory protocol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003ch2\u003eLaboratory Handling \u0026amp; Storage\u003c\/h2\u003e\n\u003cp\u003eStandard small-peptide handling: sterile technique, PPE, protection from light and moisture, and documented lot tracking.\u003c\/p\u003e\n\u003ch2\u003eCertificate of Analysis \u0026amp; Quality Assurance\u003c\/h2\u003e\n\u003cp\u003eEvery batch of Semax is verified by independent third-party HPLC analysis (identity and purity) before it ships. The certificate of analysis for the current batch is linked on this page and can be reviewed here: \u003ca href=\"https:\/\/verify.janoshik.com\/tests\/169749-Semax_10mg_SX10_6LZSYMF2NF99\" target=\"_blank\" rel=\"noopener\"\u003eview batch COA\u003c\/a\u003e. Documentation of lot number, test date, and method accompanies each batch.\u003c\/p\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eSemax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice. \u003cem\u003eBr J Pharmacol\u003c\/em\u003e. 2025. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40692165\/\" target=\"_blank\" rel=\"noopener\"\u003ePMID: 40692165\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eTherapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions. \u003cem\u003eJ Am Acad Orthop Surg Glob Res Rev\u003c\/em\u003e. 2026. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41490200\/\" target=\"_blank\" rel=\"noopener\"\u003ePMID: 41490200\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003eNote: Semax is supplied strictly for laboratory research use only. It is not approved for human or veterinary use, and nothing on this page is medical advice or a health claim. All described findings reflect preclinical or published research contexts.\u003c\/em\u003e\u003c\/p\u003e\n\u003ch2\u003eShipping, Handling \u0026amp; Guarantee\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eFast U.S. shipping:\u003c\/strong\u003e Orders placed before 2:00 PM CT ship the same business day from Minneapolis, MN. Free shipping on orders over $100.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLab safety profile:\u003c\/strong\u003e Supplied for laboratory research use only. Handle using appropriate personal protective equipment in a suitable laboratory setting. Not for human or veterinary use.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOrder guarantee:\u003c\/strong\u003e If your order arrives damaged, incorrect, or incomplete, contact us within 48 hours of delivery with photos and we will make it right. See our \u003ca href=\"\/policies\/refund-policy\"\u003eReturn \u0026amp; Refund Policy\u003c\/a\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Prestige Peptides","offers":[{"title":"10mg \/ 1 Vial","offer_id":50520206213363,"sku":"pp-smx-10-1v","price":30.0,"currency_code":"USD","in_stock":true},{"title":"10mg \/ 3 Vials","offer_id":50226742296819,"sku":"pp-smx-10-3v","price":76.5,"currency_code":"USD","in_stock":true},{"title":"10mg \/ 5 Vials","offer_id":50226742329587,"sku":"pp-smx-10-5v","price":112.5,"currency_code":"USD","in_stock":true},{"title":"10mg \/ 10 Vials","offer_id":50279141638387,"sku":null,"price":195.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0839\/9857\/2787\/files\/semax-approved-wider-panel_d8dd87e6-db65-4c31-80bb-5c82064d852d.png?v=1788221469","url":"https:\/\/prestigepeptides.us\/products\/pp-07","provider":"Prestige Peptides","version":"1.0","type":"link"}