{"product_id":"pp-03","title":"MOTS-c","description":"\u003cp\u003eMOTS-c is a 16-amino-acid mitochondrial-derived peptide studied in laboratory research on cellular energy homeostasis and metabolic-stress response pathways, including AMPK-signaling models. Supplied as lyophilized material for qualified in-vitro research.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eCompound specifications:\u003c\/strong\u003e Lyophilized powder in sealed vials. Purity verified at ≥99% by independent third-party HPLC analysis. Store in a cool, dry environment; refrigerate after reconstitution per standard laboratory protocol.\u003c\/p\u003e\u003cdiv class=\"pp-product-notes\"\u003e\n\u003cdiv class=\"pp-product-notes__item\"\u003e\n\u003cp class=\"pp-product-notes__label\"\u003eResearch use notice\u003c\/p\u003e\n\u003cp\u003eReserved for qualified in-vitro laboratory research only. Not for human consumption, veterinary use, clinical, diagnostic, or therapeutic use. Purchasers must be 21 years of age or older and accept the Research Use Only Agreement before ordering.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\n\u003ch2\u003eWhat is MOTS-c?\u003c\/h2\u003e\n\u003cp\u003eMOTS-c (mitochondrial open reading frame of the 12S rRNA-c) is a 16-amino-acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA gene. It belongs to a recently characterized class of signaling peptides produced by the mitochondrial genome, and has become a prominent subject in metabolic and exercise-physiology research models.\u003c\/p\u003e\n\u003cp\u003ePublished research describes MOTS-c as a retrograde signaling molecule — a peptide through which mitochondria communicate stress and energy status to the wider cell. It is supplied here as high-purity lyophilized material strictly for qualified research use.\u003c\/p\u003e\n\u003ch2\u003eMechanism of Action — Research Overview\u003c\/h2\u003e\n\u003cp\u003eResearch models associate MOTS-c with AMPK-pathway activation and folate-cycle\/AICAR-related metabolic signaling. Studies examine how it influences glucose utilization, fatty-acid oxidation markers, and cellular stress-adaptation responses in preclinical systems.\u003c\/p\u003e\n\u003cp\u003eA recurring theme in the literature is its exercise-mimetic character in animal models: MOTS-c levels respond to physical activity, and experimental administration is studied for effects on metabolic flexibility and age-related metabolic decline pathways.\u003c\/p\u003e\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eMitochondrial signaling and retrograde-communication research\u003c\/li\u003e\n\u003cli\u003eAMPK-pathway and cellular energy-sensing studies\u003c\/li\u003e\n\u003cli\u003eMetabolic flexibility and substrate-utilization models\u003c\/li\u003e\n\u003cli\u003eExercise-mimetic and muscle-metabolism research\u003c\/li\u003e\n\u003cli\u003eAge-related metabolic-decline pathway investigations\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eMOTS-c Specifications\u003c\/h2\u003e\n\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eFormat\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eLyophilized powder in sealed 3 mL glass vial (10mg \/ 20mg)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eCAS Number\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e1627580-64-6\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eChemical Formula\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eC101H152N28O22S2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e≈ 2174.6 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003ePubChem CID\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e146675088\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSynonyms\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eMitochondrial-derived peptide MOTS-c, mtORF-12S peptide\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eStore lyophilized at −20°C, sealed, protected from light and moisture. Refrigerate after reconstitution per standard laboratory protocol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003ch2\u003eLaboratory Handling \u0026amp; Storage\u003c\/h2\u003e\n\u003cp\u003eHandle with sterile technique and appropriate PPE. Protect from moisture and repeated freeze–thaw after reconstitution; record lot numbers in experimental documentation.\u003c\/p\u003e\n\u003ch2\u003eCertificate of Analysis \u0026amp; Quality Assurance\u003c\/h2\u003e\n\u003cp\u003eEvery batch of MOTS-c is verified by independent third-party HPLC analysis (identity and purity) before it ships. The certificate of analysis for the current batch is linked on this page and can be reviewed here: \u003ca href=\"https:\/\/verify.janoshik.com\/tests\/169209-MOTSc_1omg_MS10_SK3AJ235KIJV\" target=\"_blank\" rel=\"noopener\"\u003eview batch COA\u003c\/a\u003e. Documentation of lot number, test date, and method accompanies each batch.\u003c\/p\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eMOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation. \u003cem\u003eFront Endocrinol (Lausanne)\u003c\/em\u003e. 2023. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36761202\/\" target=\"_blank\" rel=\"noopener\"\u003ePMID: 36761202\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eThe mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. \u003cem\u003eCell Metab\u003c\/em\u003e. 2015. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25738459\/\" target=\"_blank\" rel=\"noopener\"\u003ePMID: 25738459\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003eNote: MOTS-c is supplied strictly for laboratory research use only. It is not approved for human or veterinary use, and nothing on this page is medical advice or a health claim. All described findings reflect preclinical or published research contexts.\u003c\/em\u003e\u003c\/p\u003e\n\u003ch2\u003eShipping, Handling \u0026amp; Guarantee\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eFast U.S. shipping:\u003c\/strong\u003e Orders placed before 2:00 PM CT ship the same business day from Minneapolis, MN. Free shipping on orders over $100.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLab safety profile:\u003c\/strong\u003e Supplied for laboratory research use only. Handle using appropriate personal protective equipment in a suitable laboratory setting. Not for human or veterinary use.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOrder guarantee:\u003c\/strong\u003e If your order arrives damaged, incorrect, or incomplete, contact us within 48 hours of delivery with photos and we will make it right. See our \u003ca href=\"\/policies\/refund-policy\"\u003eReturn \u0026amp; Refund Policy\u003c\/a\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Prestige Peptides","offers":[{"title":"10mg \/ 1 Vial","offer_id":50520206377203,"sku":"pp-mtc-10-1v","price":45.0,"currency_code":"USD","in_stock":true},{"title":"10mg \/ 3 Vials","offer_id":50226739773683,"sku":"pp-mtc-10-3v","price":114.75,"currency_code":"USD","in_stock":true},{"title":"10mg \/ 5 Vials","offer_id":50226739806451,"sku":"pp-mtc-10-5v","price":168.75,"currency_code":"USD","in_stock":true},{"title":"10mg \/ 10 Vials","offer_id":50279141277939,"sku":null,"price":292.5,"currency_code":"USD","in_stock":true},{"title":"20mg \/ 1 Vial","offer_id":50520206409971,"sku":"pp-mtc-20-1v","price":65.0,"currency_code":"USD","in_stock":true},{"title":"20mg \/ 3 Vials","offer_id":50226739871987,"sku":"pp-mtc-20-3v","price":165.75,"currency_code":"USD","in_stock":true},{"title":"20mg \/ 5 Vials","offer_id":50226739904755,"sku":"pp-mtc-20-5v","price":243.75,"currency_code":"USD","in_stock":true},{"title":"20mg \/ 10 Vials","offer_id":50279141310707,"sku":null,"price":422.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0839\/9857\/2787\/files\/mots-c-approved-wider-panel_b84efccf-ca01-48b6-a001-1ecdf6d8a797.png?v=1788221463","url":"https:\/\/prestigepeptides.us\/products\/pp-03","provider":"Prestige Peptides","version":"1.0","type":"link"}